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HYPERGLYCEMIA AND GLYCOSURIA AS MEANS OF CONTROLLING PROTAMINE ZINC INSULIN ADMINISTRATION IN DIABETES

Ann Intern Med. 1943;18(1):112-115. doi:10.7326/0003-4819-18-1-112
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Before insulin was discovered dietary restriction and control constituted the only therapeutic procedures which materially affected the course of diabetes. As a guide to the effectiveness of treatment, hyperglycemia and the attendant glycosuria were universally employed. Control of the glycosuria was followed by improvement, whereas failure to accomplish this meant active and progressive disease. Naunyn (1906) was among the first to formulate this observation precisely. "In many cases of diabetes glycosuria shows a decided tendency to progress. . . . But in the majority of cases the progressiveness of the glycosuria is only the expression of the bad influence which

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