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W. H. B.
Ann Intern Med. 1946;24(5):928-930. doi:10.7326/0003-4819-24-5-928
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During the past thirty years many studies on prophylactic immunization against pneumococcal pneumonia have been made with a number of different antigenic preparations. Among the earliest of these studies was that of Cecil and Austin1 who tested the effect of prophylactic vaccination against pneumococcal pneumonia at Camp Upton, New York, in 1918. Their vaccine consisted of a saline suspension of heat-killed pneumococci types I, II, and III. Almost all investigators have concluded that immunization exerts a beneficial effect. In most of the studies, however, interpretation of the results was clouded by such variables as differences in the composition of the


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