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BCG VACCINE

P. W. C.
Ann Intern Med. 1948;28(3):682-686. doi:10.7326/0003-4819-28-3-682
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The factors which determine immunity from tuberculosis differ substantially from those which are operative in the case of many other infections. Humoral antibodies appear to play at most a minor rôle, and resistance depends primarily upon an altered reactivity of the tissue cells. Although some degree of immunity may be produced in animal experiments by the inoculation of killed organisms, any notable degree of protection depends upon the presence of living tubercle bacilli in the body. All practicable methods of immunization are based upon the observation—which has been confirmed by innumerable experiments—that inoculation of animals with a strain of tubercle

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