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M. S. S.
Ann Intern Med. 1949;31(2):354-358. doi:10.7326/0003-4819-31-2-354
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Despite intensive investigation the etiology of rheumatic fever remains obscure. Important evidence has been accumulated, however, concerning a variety of contributory factors. Thus, it is generally agreed that the disease occurs more commonly under cool, damp climatic conditions than in warm, dry climates.1 Epidemiologic data also permit the generalization that a poor economic status with its corollaries of overcrowding and undernutrition provides a more fertile soil for the development of rheumatic fever than the antithetical situation.1 In addition to such external factors, careful students of the subject now firmly believe that the susceptibility to rheumatic fever is inherited as a


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