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H. J. L. M.
Ann Intern Med. 1949;31(3):524-528. doi:10.7326/0003-4819-31-3-524
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This excerpt has been provided in the absence of an abstract.

Since Withering1 established the empirical fact that the powdered leaves of foxglove were a valuable remedy for the dropsy, many of the pharmacological actions of digitalis have been elucidated. Those that have gained general acceptance are well summarized by Willius2 in three main compartments:

(a) digitalis depresses the function of the sino-auricular and the auriculo-ventricular nodes, and a tendency to slowing of the cardiac rate results;

(b) it depresses conduction throughout the cardiac muscle, particularly through the auriculo-ventricular bundle, and increases the refractory period in both the auricles and ventricles;

(c) it increases the amplitude of cardiac contraction and tends


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