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M. S. S.
Ann Intern Med. 1949;31(5):925-931. doi:10.7326/0003-4819-31-5-925
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In April, 1949 Hench et al.1 reported that the administration of one of the adrenal cortical hormones, 17-hydroxy-11-dehydrocorticosterone (Compound E), produced beneficial effects of a striking nature in a group of patients with advanced rheumatoid arthritis. Withdrawal of the hormone was followed by the recurrence of signs and symptoms of the disease. Essentially similar results were obtained in several patients who were given adrenocorticotropic hormone (ACTH) derived from hog pituitary. In a subsequent paper2 these investigators reported that the administration of compound E to three patients with acute rheumatic fever was also followed by rapid subsidence of clinical evidences of


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