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P. W. C.
Ann Intern Med. 1952;37(4):813-816. doi:10.7326/0003-4819-37-4-813
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Both the etiology and the therapeutic management of ulcerative colitis present many unsolved problems, and additional information bearing on this subject is badly needed. Recent observations indicating a relationship of lysozyme to this disease naturally have aroused much interest.

Lysozyme is a mucolytic and bacteriolytic enzyme (or rather a group of enzymes), first isolated and described by Fleming in egg white, and also in human tears and other secretions. Lysozyme is a crystallizable basic protein of relatively low molecular weight, optimally active at a pH of about 6.0. It causes hydrolysis of certain mucopolysaccharides, and it can be titrated by


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