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LYSOZYME IN ULCERATIVE COLITIS

P. W. C.
Ann Intern Med. 1952;37(4):813-816. doi:10.7326/0003-4819-37-4-813
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This excerpt has been provided in the absence of an abstract.

Both the etiology and the therapeutic management of ulcerative colitis present many unsolved problems, and additional information bearing on this subject is badly needed. Recent observations indicating a relationship of lysozyme to this disease naturally have aroused much interest.

Lysozyme is a mucolytic and bacteriolytic enzyme (or rather a group of enzymes), first isolated and described by Fleming in egg white, and also in human tears and other secretions. Lysozyme is a crystallizable basic protein of relatively low molecular weight, optimally active at a pH of about 6.0. It causes hydrolysis of certain mucopolysaccharides, and it can be titrated by

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