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PATHOGENETIC MECHANISMS IN IDIOPATHIC THROMBOCYTOPENIC PURPURA

P. W. C.
Ann Intern Med. 1953;39(2):379-382. doi:10.7326/0003-4819-39-2-379
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This syndrome has long been a puzzling problem both as to its underlying cause and its pathogenesis. Recent studies which reveal the mechanisms apparently concerned in some of these cases constitute important contributions to this subject. These "idiopathic" cases must be distinguished from primary diseases of the bone marrow, such as acute leukemia or aplastic anemia, in which the lack of platelets is a subsidiary phenomenon. It is also customary to distinguish them from those cases for which there is a demonstrable cause, such as a hypersensitive reaction to certain drugs, although in other respects clinically they may be virtually

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