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THE CLINICAL EFFECT OF ISONIAZID AND IPRONIAZID IN THE TREATMENT OF PULMONARY TUBERCULOSIS*

ROBERT G. BLOCH, M.D., F.A.C.P.; ALFRED S. DOONEIEF, M.D.; ABRAHAM S. BUCHBERG, M.D.; and STANLEY SPELLMAN, M.D.
[+] Article and Author Information

Paragraph192498*Received for publication September 11, 1953.

Paragraph192500From the Division of Pulmonary Diseases, Montefiore Hospital, N. Y., and the Westchester Division, Montefiore Hospital, Bedford Hills, N. Y.

Paragraph192502Read at the 48th Annual Meeting of The American Trudeau Society in Los Angeles, May, 1952.

Paragraph192504We wish to express our appreciation to Hoffmann-LaRoche, Inc., Nutley, New Jersey, for generously supplying us with the drugs used in this investigation.

Paragraph192506†Teaching-Resident Fellow of the National Tuberculosis Association.


Ann Intern Med. 1954;40(5):881-900. doi:10.7326/0003-4819-40-5-881
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This excerpt has been provided in the absence of an abstract.

Since the hydrazine derivatives of isonicotinic acid were first advocated as effective against tuberculosis early in 1952, there has been much serious appraisal of their therapeutic value. Isoniazid already has taken an important place in phthisiotherapy, if only because of the ease of its application and the small expense of the drug. But there is a need for extensive and prolonged clinical experimentation before the encouraging results of scarcely one year can be confirmed. Much of the early publicity campaign in the daily press about the new "miracle drugs" still lingers on, in the minds not only of the public

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