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TREATMENT OF ACUTE AND CHRONIC LEAD POISONING WITH DISODIUM CALCIUM VERSENATE*

JOHN F. WADE JR., M.D.; and JOHN F. BURNUM, M.D.
Ann Intern Med. 1955;42(2):251-259. doi:10.7326/0003-4819-42-2-251
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Until recently the treatment of lead intoxication has been generally unsatisfactory. The rapid in vivo breakdown of citrate precludes its usefulness as a lead complexing agent.1 BAL is also ineffective, and there are suggestions that the BAL-lead complex may be toxic.2 Calcium diets, acidifying agents, disodium hydrogen phosphate and other forms of therapy have met with varying success, but in the main they have not proved to be of predictable worth. The availability of disodium calcium ethylenediamine tetra-acetate (Ca EDTA), a relatively new metal chelating agent which enhances the urinary excretion of lead, offered for the first time considerable promise

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