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Ann Intern Med. 1955;43(6):1341-1346. doi:10.7326/0003-4819-43-6-1341
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The remarkable effects of corticotropin and cortisone in ameliorating the manifestations of rheumatoid arthritis, as first reported by Hench and his associates, undoubtedly marked a major advance in the treatment of this disease. Their observations have been amply confirmed. Adequate doses of cortisone, temporarily within the tolerance of the subject, will quickly relieve the pain and dissipate the evidences of acute inflammation in 95 per cent of the cases. The early enthusiasm was soon chilled, however, by the serious adverse effects caused by full doses of the drug and by the promptness and great regularity with which relapse followed an


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