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Ann Intern Med. 1956;44(6):1270-1275. doi:10.7326/0003-4819-44-6-1270
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Marked enhancement of various agglutination reactions by non-immune serum was occasionally reported during the early decades of the present century, but the possible clinical significance of this phenomenon was not recognized until 1940 when Waaler1 reported that approximately 35% of sera from patients with rheumatoid arthritis possessed such a property in contrast to less than 5% of a control series. Perhaps as a result of the intervention of the war, this work was completely lost sight of until the phenomenon was rediscovered by Rose and coworkers2 who found significant enhancement of agglutination by 80% of rheumatoid sera as compared with


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