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Ann Intern Med. 1956;45(3):550-555. doi:10.7326/0003-4819-45-3-550
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For a long time clinical investigators have postulated that the etiology of rheumatoid arthritis might have metabolic implications. At one time the parathyroid glands were considered to have an important relationship to the disease, and it was believed that parathyroid dysfunction caused the changes in the bones and joints. Hyperthyroidism and hypothyroidism have likewise been considered to have an etiologic linkage in the pathogenesis of this disease. Careful studies, however, have failed to reveal a relationship of any of these endocrinologic disorders to rheumatoid arthritis.

On the other hand, there are certain clinical characteristics of the disease, i.e., profound muscle


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