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The Genesis and Prevention of Cancer.

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2nd Ed. By HANDLEY W. SAMPSON. , M.S. London, F.R.C.S. 320 pages; 14 X 21.5 cm. The Macmillan Co., New York: . 1955.. Price, $4.00.

Ann Intern Med. 1956;45(5):970-971. doi:10.7326/0003-4819-45-5-970_2
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Mr. Handley has painstakingly marshalled a mass of data to support his views on the genesis of cancer. The author takes issue with the present-day irritation theory of cancer causation. The reviewer is impressed with the evidence presented to support Mr. Handley's conclusion that pre-cancerous lesions are lesions in which the lymphatic vessels have been blocked or obliterated by chronic inflammation or congenital defect. However, despite careful rereading of the significant chapters, the reviewer is still uncertain whether the lymph stasis precedes the pre-cancer or whether the two conditions co-exist, or whether the lymph stasis is the result of the


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