COMA AFTER MILTOWN OVERDOSE
Publication: Annals of Internal Medicine
Volume 45, Number 6
Excerpt
The anxiety states are so common that new sedative drugs are constantly being sought. Recently, the propanediol derivatives seemed to be among the most promising. The newest compound of this type is meprobamate (Miltown) (2-methyl-2-N-propyl-1,3-propanediol dicarbamate). The chemical was first synthesized in 1950 by Ludwig and Piech.1 The pharmacology was first described by Berger.2, 3 He demonstrated that it produces muscle relaxation and sedation through its action on the central nervous system by its inhibiting effect on the internuncial circuits. It is considered a practical, safe and clinically useful central nervous system depressant.
Borrus4treated 67 patients with no ill...
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Bibliography
1.
Ludwig BJ and Piech EC: Some anticonvulsant agents derived from 1,3-propanediols, J. Am. Chem. Soc. 73: 5779, 1951.
2.
Berger FM: The pharmacological properties of 2-methyl-2-N-propyl-1,3-propanediol dicarbamate (Miltown), a new interneuronal blocking agent, J. Pharmacol. and Exper. Therap. 112: 413 (Dec.) 1954.
3.
Hendley CD, Lynes TE, and Berger FM: Effect of 2-methyl-2-N-propyl-1, 3-propanediol dicarbamate (Miltown) on central nervous system, Proc. Soc. Exper. Biol. and Med. 87: 608 (Dec.) 1954.
4.
Borrus JC: Study of effect of Miltown (2-methyl-2-N-propyl-1, 3-propanediol dicarbamate) on psychiatric states, J. A. M. A. 157: 1596 (Apr. 30) 1955.
5.
Selling LS: Clinical study of a new tranquilizing drug, J. A. M. A. 157: 1594 (Apr. 30) 1955.
6.
Lemere F: New tranquilizing drugs, Northwest Med. 54: 1098 (Oct.) 1955.
7.
Berger FM: Personal communcation.
Information & Authors
Information
Published In
Annals of Internal Medicine
Volume 45 • Number 6 • 1 December 1956
Pages: 1211 - 1213
History
Published in issue: 1 December 1956
Published online: 1 December 2008
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COMA AFTER MILTOWN OVERDOSE. Ann Intern Med.1956;45:1211-1213. doi:10.7326/0003-4819-45-6-1211
COMA AFTER MILTOWN OVERDOSE. Ann Intern Med.1956;45:1211-1213. doi:10.7326/0003-4819-45-6-1211
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