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D. H. NELSON, M.D.; J. W. MEAKIN, M.D.; and G. W. THORN, M.D., F.A.C.P.
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*Received for publication August 10, 1959.Presented in part at the Fifty-first Annual Meeting of the American Society for Clinical Investigation, Atlantic City, New Jersey, May, 1959.From the Department of Medicine, Harvard Medical School, and the Peter Bent Brigham Hospital, Boston, Massachusetts.†These investigations were supported in part by grants from the United States Public Health Service, Grant A-19 (C-9), and the John A. Hartford Foundation, Inc., New York, N. Y.‡Investigator, Howard Hughes Medical Institute.§Life Insurance Medical Research Fellow (1958-1959).Requests for reprints should be addressed to D. H. Nelson, M.D., Director, Metabolic Unit, Peter Bent Brigham Hospital, Boston 15, Massachusetts.

Ann Intern Med. 1960;52(3):560-569. doi:10.7326/0003-4819-52-3-560
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This excerpt has been provided in the absence of an abstract.

Since describing a single patient who, following bilateral adrenalectomy for Cushing's syndrome associated with adrenal hyperplasia, subsequently developed an ACTH-producing tumor of the pituitary gland, we have had the opportunity to study or to determine plasma-ACTH levels on a total of nine other similar patients.1 It is the purpose of this study to report one additional patient in detail, and to describe the clinical picture presented by these patients. Preliminary evidence concerning the therapy of this condition is also given. In none of the patients to be described was there evidence of a tumor of the pituitary gland prior to


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