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Ann Intern Med. 1960;52(5):1161-1169. doi:10.7326/0003-4819-52-5-1161
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Methods for controlling several human diseases of major importance through immunoprophylaxis have been available for some time. Protection of man against smallpox by the use of vaccinia virus has been known for over a century and complete eradication of this disease only awaits the universal application of adequate vaccination programs. Prevention of diphtheria and tetanus with toxins deprived of their lethal properties but not of their antigenicity by chemical modification represents another great advance in the field of immunization. More recently, the production of effective pertussis vaccines and the advent of poliomyelitis vaccine have increased even further the potential of




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