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Ann Intern Med. 1960;53(4):848-853. doi:10.7326/0003-4819-53-4-848
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Neuropsychiatry disturbances progressing at times to actual coma have been recognized for many years as a not infrequent complication of the terminal stages of cirrhosis. In fact excerpts from medical writers of antiquity have been quoted as possibly descriptions of such a condition. It has been recognized for many years that this "hepatic coma" was quite distinct from uremic and diabetic coma and that it was not associated with intracranial lesions or other generally recognized causes of such psychic disturbances. Until recently, however, nothing precise was known regarding its pathogenesis.

The first major lead to an understanding of this condition


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