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Studies of the Pathogenesis of Human Hypertension: The Adrenal Cortex and Renal Pressor Mechanism

JACQUES GENEST, M.D., F.R.C.P., (C)F.A.C.P.; P. BIRON, M.D.; E. KOIW, PHYS. ENG.; W. NOWACZYNSKI, D.SC.; R. BOUCHER, PH.D.; and M. CHRÉTIEN, M.D.
Ann Intern Med. 1961;55(1):12-28. doi:10.7326/0003-4819-55-1-12
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At the meeting of The American College of Physicians in Los Angeles in 1956 we reported our preliminary findings of a significantly greater urinary aldosterone excretion in patients with severe essential and malignant hypertension than in normal subjects. This study was based on a biological determination of a purified aldosterone fraction obtained after two successive chromatographic purifications of the crude, neutral extract of acidified urine (1). These studies of the relationship of adrenocortical hormones to hypertensive disease have been continued and, by using a more specific physicochemical method for the isolation and determination of urinary aldosterone, have been extended to

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