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Agranulocytosis Associated with Tofranil

Ann Intern Med. 1961;55(2):321-323. doi:10.7326/0003-4819-55-2-321
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The multiplicity of toxic side effects from many of the newer synthetic drugs can hardly be enumerated, and these will undoubtedly continue to increase as more potent preparations are marketed. This is not to imply that their danger is so grave as to preclude their use, since in most cases the incidence of serious complications is low and can largely be avoided by careful observation of the patient. The reports of individual cases of new reactions, therefore, have great merit in bringing to light serious toxic reactions which are not generally recognized. These most often occur in oversensitive patients after


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