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Plasma Fibrinogen in Familial Mediterranean Fever

Ann Intern Med. 1961;55(3):448-455. doi:10.7326/0003-4819-55-3-448
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A rise in the plasma fibrinogen level is a nonspecific body response which occurs in many pathological states, resembling in this respect an increase in the erythrocyte sedimentation rate. Indeed, the fibrinogen level is one of the principal factors influencing the erythrocyte sedimentation rate (1). Little is known of the mechanism which controls the fibrinogen level in health and disease, or of the possible functions of fibrinogen other than its role in blood clotting. The possibility of qualitative differences in the fibrinogen in various disorders has hardly been explored, most studies having been concerned only with quantitative aspects.

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