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Pneumococcal Meningitis in the Adult: Clinical, Therapeutic, and Prognostic Aspects in Forty-three Patients

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Copyright, ©, 1961, by The American College of PhysiciansThe American College of Physicians

Ann Intern Med. 1961;55(4):545-549. doi:10.7326/0003-4819-55-4-545
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The pneumococcus is uniquely susceptible to penicillin. Despite widespread use, this antibiotic remains bactericidal for the pneumococcus at low concentrations, and no resistant strains have emerged. The unusual characteristics of this microorganism have resulted in a uniformly low mortality for pneumococcal infections generally, and the virtual disappearance of pneumococcal pneumonia as a therapeutic problem.

Pneumococcal meningitis, however, appears to be an exception to these facts. Mortality varies from as low as 7 to as high as 72% in some series (1-3). This paper is a review of our experience with pneumococcal meningitis in 43 adult patients seen during the years


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