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Caplan's Syndrome: An Interesting Clinico-pathological Occurrence

Ann Intern Med. 1961;55(4):667-672. doi:10.7326/0003-4819-55-4-667
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In 1953, Caplan described a new syndrome in which rheumatoid arthritis was associated with nodular fibrosis of the lungs (1). This condition resembled progressive massive fibrosis or conglomeration of the shadows, as it is more commonly known in the United States, but had distinctive features. A later publication studied the epidemiology of Caplan's syndrome and added some further knowledge to an interesting clinico-pathological occurrence (2). A patient with this syndrome is described here. It is pertinent to note that this patient had been seen on numerous occasions in several clinics over a period of years, without the syndrome being recognized


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