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Peptic Ulcer in Primary Hyperparathyroidism: An Analysis of Fifty-two Cases

W. T. WILDER, M.D.; BOY FRAME, M.D., F.A.C.P.; and W. S. HAUBRICH, M.D.
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Copyright ©, 1961, by The American College of PhysiciansThe American College of Physicians


Ann Intern Med. 1961;55(6):885-893. doi:10.7326/0003-4819-55-6-885
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Recent medical experience suggests that an awareness of the association between peptic ulcer and hyperparathyroidism may increase the yield of early diagnosis in primary hyperparathyroidism. This paper analyzes the clinical relationships in 52 patients who had both hyperparathyroidism and peptic ulcer.

Fourteen cases of parathyroid adenoma were proven at Henry Ford Hospital between 1934 and 1957, and in none of these was there a history of peptic ulcer. On the other hand, between 1958 and 1960, seven of ten proven cases of hyperparathyroidism exhibited peptic ulcer either before or at the time parathyroid hyperfunction was diagnosed (Table 1). Four of

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