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"Purple Toes": an Uncommon Sequela of Oral Coumarin Drug Therapy

Ann Intern Med. 1961;55(6):911-917. doi:10.7326/0003-4819-55-6-911
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The utility of coumarin type anticoagulants during the acute stage of many types of thrombo-embolic incidents, including myocardial infarction, has been well established clinically. More recently, the efficacy of these drugs for long-term prophylaxis has also been shown to be of value (1-4), and there is an increasing population of patients on long-term oral anticoagulant therapy. The purpose of this paper is to describe a dermatologic side effect of such therapy, which, to the best of our knowledge, has not been reported previously.

Our attention was directed to six patients who developed a dark blue-tinged bilateral purple discoloration of the



coumarins ; toes

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