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Ann Intern Med. 1961;55(6):943-957. doi:10.7326/0003-4819-55-6-943
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Amyloidosis is a disease of unknown cause characterized by the accumulation of an amorphous, proteinaceous material in various organs and tissues of the body. Rokitansky (1), in 1842, is usually credited with the first description of the disease in association with chronic sepsis. It remained for Virchow, ten years later, to attach the name amyloid. Wild, in 1886, first described a form of amyloidosis not associated with a preceding chronic disease (2).

The purpose of this paper is to report the findings in 73 autopsied cases and to review certain concepts and manifestations of amyloidosis.

The classification advanced by Reimann,




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