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Functioning Islet Cell Adenoma with a Note about Leucine Sensitivity

Ann Intern Med. 1961;55(6):998-1001. doi:10.7326/0003-4819-55-6-998
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The occurrence of hypoglycemia as a result of excessive insulin production by islet cell tumors of the pancreas is well documented (1, 2). However, the demonstration of the tumor preoperatively is difficult since the pancreatic lesion is usually small and rarely produces symptoms because of its position. Nor do lowered blood sugar levels necessarily mean functioning islet cell tumor, inasmuch as hypoglycemia is a manifestation of diseases such as adrenal insufficiency, pituitary failure, or some large sarcomas (3) and also occurs in the absence of demonstrable lesions in children with idiopathic hypoglycemia (4), in adults with functional hypoglycemia (5), and


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