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Drug Therapy and the Etiology of Systemic Lupus Erythematosus

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Department of Medicine
The University of Alabama Medical Center
Medical College of Alabama
Birmingham 3, Alabama

Ann Intern Med. 1961;55(6):1036-1039. doi:10.7326/0003-4819-55-6-1036
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Although many theories concerning the cause of lupus erythematosus (SLE) have been advanced, the precise etiology of this disorder remains obscure. Most investigators now believe that the symptomatology and ultimate pathology in this condition are attendant upon an abnormal hypersensitivity state. Evidence for this concept is the occurrence of antibody activity in a variety of plasma proteins to various cell types of the human body during the course of the disease (1). Although these antibodies vary from patient to patient, their appearance and disappearance are related to the activity and inactivity, respectively, of the disease process (2).

Reports of the


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