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A Clinicopathological Study of the Nephrotic Syndrome

Ann Intern Med. 1962;56(1):54-67. doi:10.7326/0003-4819-56-1-54
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The nephrotic syndrome is a disorder of diverse causes which occurs as a primary or secondary form of renal disease and exhibits variable pathologic features (1-8). Its etiologic and pathologic variations pose many problems of diagnosis and therapy. However, a pathologic diagnosis can now be made by a percutaneous renal biopsy. Such biopsies have revealed the broad spectrum of histopathologic changes found in the group of diseases responsible for the nephrotic syndrome (5-14). The multiple glomerular changes revealed by renal biopsies may help to explain the marked variation in the clinical course, as well as unpredictable and variable responses to


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