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The Relation of Pulse Rate to Renal Function in a Patient with Aortic Insufficiency

Ann Intern Med. 1962;56(1):94-96. doi:10.7326/0003-4819-56-1-94
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Within limits, pulse rate is unrelated normally to cardiac output. In the presence of free aortic regurgitation, however, the ability of the heart to increase effective stroke volume to compensate for bradycardia is severely limited. This has been demonstrated by Pearce and Nordyke (1) who noted a decrease in the mean arterial blood pressure of a patient with aortic insufficiency when the heart rate was slowed. Selkurt, Hall, and Spencer (2) showed that glomerular filtration and urine flow cease in the dog, when the mean perfusion pressure falls below 60 millimeters of mercury. With severe aortic insufficiency, pulse rates below


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