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Hypo- and Hypernatremia

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University of North Carolina School of Medicine
Chapel Hill, North Carolina

Ann Intern Med. 1962;56(1):161-164. doi:10.7326/0003-4819-56-1-161
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Abnormal values for the concentration of sodium in serum are common in clinical practice. These altered values are more often depressed than elevated; and although they sometimes are of trivial concern, they are more often reflective of serious dislocations of the internal environment which arise from the consequences of a disease process and may be the hallmark of a life-threatening status. Assuming that there is no laboratory error, that there is normoglycemia (1), and that the serum has the usual content of water, that is, there is no significant hyperlipemia nor hyperproteinemia (2), the concentration of sodium in the serum




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