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Studies on the Antibiotic Therapy of Serious Staphylococcal Infections: I. Comparison of the In Vitro Activity of Methicillin, Phenethicillin, and Other Antibiotics

Ann Intern Med. 1962;56(2):198-206. doi:10.7326/0003-4819-56-2-198
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Hospital-acquired staphylococcal infections will continue as a serious problem so long as advances in medicine and surgery result in the prolongation of the lives of patients whose impaired resistance to infection remains unaltered. A guarded optimism for the future is justifiable in the light of rapidly increasing knowledge of the pathogenesis and epidemiology of staphylococcal infections and because of the development of new and effective antibiotics. There is general agreement that penicillin G is the ideal antistaphylococcal agent if the organism is sensitive to it (1, 2), but the saturation of hospitals with organisms which produce penicillinase has made sensitivity


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