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Pseudohypoparathyroidism and Hypothyroidism

Ann Intern Med. 1962;56(2):276-281. doi:10.7326/0003-4819-56-2-276
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In 1939 Drake and his colleagues (1) set forth the criteria necessary for a diagnosis of chronic idiopathic hypoparathyroidism. These included decreased serum calcium and increased serum inorganic phosphorus levels associated with tetany, and, often, developmental abnormalities of the teeth, and cataracts. Such a diagnosis precludes evidence of osteomalacia, steatorrhea, or chronic renal insufficiency by which the altered serum calcium-phosphorus ratio might otherwise be explained. It had been shown earlier (2) that prompt phosphorus diuresis followed the administration of parathyroid hormone in normal subjects and in patients with hypoparathyroidism, demonstrating an ability to respond to the hormone. In 1942 Albright,


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