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Immunocytochemical Observations in Periarteritis Nodosa

Ann Intern Med. 1962;56(2):289-296. doi:10.7326/0003-4819-56-2-289
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The pathogenesis of periarteritis is controversial. Apparently it is not a nosologic entity, but a collective designation for various forms of arteritis with different pathogeneses. Clinical, anatomo-pathologic, and experimental observations suggest that in certain forms of necrotizing arteritis, hypertension may play a role (1-3). Allergy as an etiologic factor was first postulated by Gruber (4) and later by others (5-8). The experiments of Masugi and Sato (9) and Rich and Gregory (10) appeared to support this concept. The classification of Zeek (11) makes allowance for different forms of necrotizing arteritis in man based on more than one pathogenetic mechanism. The


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