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Hemorrhagic and Interstitial Pneumonitis with Nephritis

Ann Intern Med. 1962;56(2):296-302. doi:10.7326/0003-4819-56-2-296
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In 1955 Parkin and others (1) reported a group of cases of hemorrhagic and interstitial pneumonitis with nephritis whose pathogenesis was thought to involve a hypersensitivity reaction. In some, penicillin was suspected as the offending allergen.

The role of allergy in the production of fulminating visceral and vascular disease, first suggested early in this century (2), has received considerable attention in recent years with much speculation whether local Arthus phenomena or altered reactivity might account for such entities as Loeffler's syndrome, Wegener's granulomatosis, and polyarteritis nodosa (3). The possibility that drugs could be involved in the pathogenesis of the latter


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