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Focal Glomerular Lesions in Fungal Endocarditis

Ann Intern Med. 1962;56(4):610-618. doi:10.7326/0003-4819-56-4-610
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Focal areas of necrosis and sclerosis have frequently been seen in the renal glomeruli of autopsied patients with subacute endocarditis due to bacteria. These glomerular lesions have been called "focal embolic (endocarditic) glomerulonephritis," with the implication that they were the result of multiple small emboli, which were dislodged from cardiac vegetations and landed in the glomerular capillaries. Allen (1) summarized the reasons for rejecting the embolic theory of the pathogenesis of these lesions and agreed with Longcope (2) who considered these lesions to be of an allergic nature. Since fungal infections in man are commonly associated with manifestations of hypersensitivity


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