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Abstracts |

Gross Left Atrial Enlargement without Pressure Elevation in Severe Mitral Regurgitation.

W. C. Awe, M.D.; and E. Braunwald, M.D. (Assoc.)
Ann Intern Med. 1962;56(4):665. doi:10.7326/0003-4819-56-4-665_1
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Generally, it has been thought that significant elevation of the left atrial and pulmonary vascular pressures occurs in patients with mitral regurgitation of sufficient severity to produce serious disability and gross enlargement of the left atrium. Nine patients with mitral regurgitation have been encountered in whom gross left atrial enlargement was accompanied by normal left atrial and pulmonary artery pressures. These patients ranged in age from eight to 49 years, all were in functional classes III or IV, with an average duration of symptoms of 7.3 years. Atrial fibrillation and the physical findings of pure mitral regurgitation were present in


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