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Increased Incidence of Cardiovascular Disease in Castrated Women: Two-year Follow-up Studies.

N. Higano, M.D.; W. D. Cohen, Ph.D.; and R. W. Robinson, M.D., F.A.C.P.
Ann Intern Med. 1962;56(4):667. doi:10.7326/0003-4819-56-4-667_3
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A previous study from this laboratory has established that patients who underwent bilateral oophorectomy prior to age 45 suffered far more atherosclerotic disease than did a group of non-castrates who had undergone hysterectomy with or without unilateral oophorectomy. None of these women had received estrogen-replacement therapy. Seventy-eight per cent (167/214) have now been reevaluated two to three years later. Eighteen definite new cardiovascular events have occurred in the 86 castrates, but there have been none in 81 non-castrates. This difference is highly significant by the Fisher-Yates Chi-square test (χ2 = 16.9, N = 1, P < .005). Additional evidence for


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