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Abstracts |

Clinical and Biochemical Studies in Patients with Functioning Islet Cell Tumors.

J. B. Field, M.D.
Ann Intern Med. 1962;56(4):674. doi:10.7326/0003-4819-56-4-674_1
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Functioning islet cell tumors frequently pose diagnostic problems. Of four patients recently studied, one was admitted to the neurosurgical service for temporal lobectomy for petit mal seizures, and another had been under intermittent psychiatric treatment for three years. They all fulfilled Whipple's triad when they were appropriately tested. The one patient tested with I.V. orinase gave a positive response. Two of the patients developed hypoglycemia after ingestion of 150 mg/kg L-leucine, but not after isoleucine, valine, or other amino acids. In one of these patients, hypoglycemia was produced by oral isovaleric acid but not by β-OH, β-CHsu>3 glutaric acid,


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