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Increased Incidence of Gout and Hyperuricemia in Adrenalectomy Patients.

H. D. Itskovitz, M.D.; and A. M. Sellers, M.D., F.A.C.P.
Ann Intern Med. 1962;56(4):675. doi:10.7326/0003-4819-56-4-675_3
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Acute gouty arthritis has been observed in eight of 104 patients surviving adrenalectomy and sympathectomy performed during the past ten years for treatment of severe arterial hypertension. An additional three patients have symptoms of arthritis not wholly typical of gout, but accompanied by elevated uric acid levels. Hyperuricemia has been found in 28 of 35 patients tested.

The incidence of gout in this series is greater than ten times that observed in other surveys; this increase is statistically significant. Similarly, the 75% occurrence of hyperuricemia without gout is substantially greater than the expected incidence of 5% found in the general


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