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Hypocalcemia and Hypophosphatemia Accompanying Osteoblastic Osseous Metastases: Studies of Calcium and Phosphate Metabolism and Parathyroid Function.

G. D. Ludwig, M.D.
Ann Intern Med. 1962;56(4):676-677. doi:10.7326/0003-4819-56-4-676_3
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The medical literature contains few reports of hypocalcemia accompanying osteoblastic osseous metastases, and the combination of hypocalcemia and hypophosphatemia accompanying such lesions has not been described previously. Five patients displaying hypocalcemia in association with osteoblastic metastases form the substance of this report. Two of them, whose primary lesions were carcinoma of the prostate gland, also had marked hypophosphatemia, and, in both, estrogen therapy appeared to induce the hypocalcemia and hypophosphatemia. A third patient having osteoblastic metastases from prostate carcinoma also developed hypocalcemia only after estrogenic therapy, but the serum phosphate remained normal. The other two patients, who were never given


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