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Abstracts |

Adrenocortical Function in Carcinoma of the Lung with and without Cushing's Syndrome.

L. J. Marks, M.D. (Assoc.)
Ann Intern Med. 1962;56(4):677. doi:10.7326/0003-4819-56-4-677_1
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Adrenocortical function was studied in 44 patients with carcinoma of the lung by measuring their plasma 17-hydroxycorticosteroid response to adrenocorticotrophic hormone. Although Cushing's syndrome was not present in any of these subjects, 36% demonstrated an exaggerated plasma corticosteroid response to ACTH. The results of the adrenal function studies could be correlated better with the severity of the patient's clinical illness than with either a specific cell type of lung cancer or the alterations in the adrenals observed at autopsy. Bio-assays of the pituitary glands for ACTH were performed for seven cases who died from lung cancer, using hypophysectomized rats. The


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