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Esophageal Motor Disturbance Induced by Acid Perfusion in Patients with Esophagitis.

C. I. Siegel, M.D.; and T. R. Hendrix, M.D.
Ann Intern Med. 1962;56(4):680-681. doi:10.7326/0003-4819-56-4-680_3
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The failure to find endoscopic and histologic evidence of inflammation in all patients with the clinical diagnosis of esophagitis led to an investigation of the esophageal motor function in these patients. Twenty-five patients with the clinical diagnosis of esophagitis were studied by esophagoscopy, esophageal biopsy, and acid perfusion with simultaneous manometric recording from the lower esophagus. This group was compared with a control group of 25 patients who did not have esophageal symptoms. Motor activity was recorded through open-tipped catheters during perfusion for three test periods: first, saline; second, 0.1 normal hydrochloric acid; and third, saline. In all 25 patients


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