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Abstracts |

Fertility and Conception Control.

G. Pincus, M.D.
Ann Intern Med. 1962;56(4):682. doi:10.7326/0003-4819-56-4-682_3
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Two major causes of infertility, anovulation and ovum blighting, may be imitated experimentally in animals by ovulation inhibition and anti-progestational compounds. Extensive investigations of natural and synthetic steroids in animals disclose: (a) highly potent ovulation inhibitors which are also active progestins; (b) certain substances exhibiting potency greater in oral administration than by parenteral administration; (c) anti-progestins of two types, estrogenic and competitive inhibitors; and (d) significant ovum blighting by anti-progestins.

Clinical trials with two highly active steroidal ovulation inhibitors, norethynodrel and ethynodiol diacetate confirm studies made on animals which indicate the superior potency of the latter, particularly when orally administered.

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