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Abstracts |

Abnormalities of Albumin Metabolism in Patients with Hypogammaglobulinemia.

T. A. Waldmann, M.D.; and L. Laster, M.D.
Ann Intern Med. 1962;56(4):692-693. doi:10.7326/0003-4819-56-4-692_3
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The electrophoretic patterns of serum proteins of 20 patients with deficient synthesis of gamma globulin revealed that in 15 the serum albumin concentration was less than 3.5 g/100 ml, and in six of these it was under 2.5 g/100 ml. The hypoalbuminemia associated with hypogammaglobulinemia was investigated by using intravenously-injected albumin-radioactive iodine and polyvinylpyrrolidine (PVP)-radioactive iodine to assess albumin synthesis and enteric loss of albumin.

Six patients with decreased serum and total body albumin were studied. Each had significant diarrhea and steatorrhea. In three, albumin synthesis was markedly impaired but a normal survival time of albumin-I131 (disappearance rate, 18 to


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