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Clinical Features of Thirty-eight Cases of Adrenal Carcinoma.

M. B. Lipsett, M.D. (Assoc.); G. T. Ross, M.D.; and R. Hertz, M.D., F.A.C.P.
Ann Intern Med. 1962;56(4):694. doi:10.7326/0003-4819-56-4-694_2
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The insidious growth and highly lethal nature of adrenal carcinoma are often insufficiently emphasized because of the subsequent dramatic manifestations of hyperadrenocorticism. Since neoplastic adrenocortical tissue is relatively inefficient in steroid production, the diagnosis of functional adrenal carcinoma is seldom made before the tumor mass is large. The retroperitoneal origin of the tumor further increases the difficulty of early diagnosis.

The 38 (15 male, 23 female) patients with adrenal cancer had a median age of 35 years (range, 1 to 62) at the onset of symptoms, and the median duration of life from the onset of symptoms was three years


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