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Abstracts |

The Interrelationships of Pulmonary Surface Tension, Ventilation, and Circulation.

J. A. Clements, M.D.
Ann Intern Med. 1962;56(4):695. doi:10.7326/0003-4819-56-4-695_3
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Since it was demonstrated that normal mammalian lungs maintain favorable surface propties by secreting in the terminal air spaces lipoprotein rich in phospholipid, interest has grown in the normal role of such intrinsic surfactant and its possible alterations in pulmonary dysfunction. The presentation consists of four parts: [1] a brief review of experimental evidence proving that surfactant is present in normal lungs and leading to discussion of its effects on mechanical properties of lungs and on ventilation and of effects of exogenous surfactant on these properties, [2] current status of certain surface lesions of the alveolar structure which are thought


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