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Detection of Deficient Erythrocyte Regeneration of Reduced Triphosphopyridine Nucleotide from Glucose-6-Phosphate: Evaluation of a Rapid Screening Test

A. P. KRAUS, M.D., F.A.C.P.; C. L. NEELY, M.D.; F. T. CAREY, M.D.; and L. M. KRAUS, PH.D.
Ann Intern Med. 1962;56(5_Part_1):765-773. doi:10.7326/0003-4819-56-5-765
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The treatment of malaria by the 8-aminoquinoline compounds was accompanied by a small incidence of hemolytic anemia (1, 2) particularly in the pigmented races. Dern et al. (3), in 1954, utilizing chromium-51 tagged erythrocytes demonstrated the abnormality to be an intracorpuscular defect. Fegler (4) noted that erythrocytes did not hemolyze in vitro until the reduced glutathione (GSH) fell below 40 mg per 100 ml red blood cells. Benesch and Benesch (5) demonstrated that blockage of erythrocyte sulfhydryl groups by arsenite resulted in hemolysis. Since glutathione constitutes the principal source of sulfhydryl groups in the erythrocyte, this finding suggested that it


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