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Acute Tubular Necrosis: Report of a Case with Failure to Recover after Sixty-seven Days of Oliguria

PETER A. F. MORRIN, M.B., B.CH.; W. BURTON GEDNEY, M.D.; WERNER BARTH, M.D.; and R. H. HEPTINSTALL, M.D.
Ann Intern Med. 1962;56(6):925-930. doi:10.7326/0003-4819-56-6-925
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It is generally believed that acute tubular necrosis is a potentially reversible disease if life can be sustained until tubular regeneration occurs (1-6). This report presents a case of acute tubular necrosis following exposure to carbon tetrachloride, in which severe oliguria persisted until death 71 days after exposure, despite histological evidence of renal tubular regeneration.

CASE REPORT: J. J., a 34-year-old Negro male, was admitted to Barnes Hospital, Saint Louis, Missouri, on February 8, 1961, with complaints of malaise, nausea, anorexia, vomiting, and passing small quantities of dark urine. Eight days prior to admission the patient had been exposed to

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