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Gastrointestinal Polyposis Associated with Alopecia, Pigmentation, and Atrophy of the Fingernails and Toenails

M. M. JOHNSTON, M.D.; J. W. VOSBURGH, M.D.; A. T. WIENS, M.D.; and G. C. WALSH, M.D., C.M., F.R.C.P. (C), F.A.C.P.
Ann Intern Med. 1962;56(6):935-940. doi:10.7326/0003-4819-56-6-935
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This excerpt has been provided in the absence of an abstract.

Recently we have encountered a patient with alopecia, pigmentation of the hands and arms, and atrophy of the fingernails and toenails associated with gastrointestinal polyposis. A review of the literature has revealed that this case is not unique, Cronkhite and Canada (1) in 1955 having described the syndrome in 2 patients.

This paper presents the case history and the results of certain studies in this patient, then discusses the syndrome with particular reference to the pathophysiological aspects; finally this condition is compared with other intestinal disorders associated with changes in ectodermal structures.

CASE REPORT: The patient was a 51-year-old Canadian-born


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